Experimental models of hospital-acquired infections after traumatic brain injury: Challenges and opportunities

N Gandasasmita, J Li, DJ Loane… - Journal of …, 2024 - liebertpub.com
Patients hospitalized after a moderate or severe traumatic brain injury (TBI) are at increased
risk of nosocomial infections, including bacterial pneumonia and other upper respiratory …

New insights into metabolism dysregulation after TBI

HC Oft, DW Simon, D Sun - Journal of neuroinflammation, 2024 - Springer
Traumatic brain injury (TBI) remains a leading cause of death and disability that places a
great physical, social, and financial burden on individuals and the health system. In this …

Innate and peripheral immune alterations after traumatic brain injury are regulated in a gut microbiota-dependent manner in mice

M Celorrio, K Shumilov, R Rodgers… - Journal of …, 2023 - liebertpub.com
Traumatic brain injury (TBI) patients are at high risk for disruption of the gut microbiome.
Previously, we have demonstrated that broad-spectrum antibiotic exposure after TBI …

The Gut-Brain Axis and Neuroinflammation in Traumatic Brain Injury

MO Oyovwi, OA Udi - Molecular Neurobiology, 2024 - Springer
Traumatic brain injury (TBI) is a major global disability and mortality cause, with the gut-brain
axis playing a crucial role in its pathophysiology. Neuroinflammation, triggered by microglia …

Binary classification model of machine learning detected altered gut integrity in controlled-cortical impact model of traumatic brain injury

Z Rahman, T Pasam, Rishab… - International Journal of …, 2024 - Taylor & Francis
Aim of the study: To examine the effect of controlled-cortical impact (CCI), a preclinical
model of traumatic brain injury (TBI), on intestinal integrity using a binary classification …

Environmental enrichment-induced cognitive recovery after a moderate pediatric traumatic brain injury is associated with the gut microbiota and neuroinflammation

J Zamudio-Flores, D Cerqueda, B Phillips-Farfán… - Experimental …, 2025 - Elsevier
Pediatric traumatic brain injury (TBI) is a significant health concern, yet access to
rehabilitation therapies for children remains limited. Environmental enrichment (EE) is a …

Non-communicable neurological disorders and neuroinflammation

C Ballerini, AK Njamnshi, SL Juliano… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury, stroke, and neurodegenerative diseases represent a major cause of
morbidity and mortality in Africa, as in the rest of the world. Traumatic brain and spinal cord …

Curcumin alleviates traumatic brain injury induced by gas explosion through modulating gut microbiota and suppressing the LPS/TLR4/MyD88/NF-κB pathway

X Dong, L Deng, Y Su, X Han, S Yao, W Wu… - … Science and Pollution …, 2024 - Springer
Gas explosions (GE) are a prevalent and widespread cause of traumatic brain injury (TBI) in
coal miners. However, the impact and mechanism of curcumin on GE-induced TBI in rats …

Evaluating the complex systems approach to persisting post-concussion symptoms

K Nielsen, J Faulkner - Theory & Psychology, 2024 - journals.sagepub.com
Persisting post-concussion symptoms (PPCS) refers to a heterogenous cluster of difficulties
experienced by a significant proportion of individuals following mild traumatic brain injury …

Gut Microbial Composition Is Associated with Symptom Self-Report in Trauma-Exposed Iraq and Afghanistan Veterans

YI Li, K Pagulayan, H Rau, R Hendrickson… - Neurotrauma …, 2025 - liebertpub.com
Iraq and Afghanistan War-era Veterans are at elevated risk for physical injuries and
psychiatric illnesses, in particular the polytrauma triad of mild traumatic brain injury (mTBI) …