Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from
Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have …

The crotonase fold is generated by a framework of four repeats of a ββα-unit, extended by
two helical regions. The active site of crotonase superfamily (CS) enzymes is located at the …

Pelletierine, a proposed building block of Lycopodium alkaloids (LAs), was demonstrated to
be synthesized via the non-enzymatic Mannich-like condensation of Δ1-piperideine and 3 …

The β‐lactam classes of antibacterials are preeminent in the treatment of bacterial infection
due to their unparalleled clinical efficacy and clinical safety. Following the discovery of the …

Curacin A is a mixed polyketide/nonribosomal peptide possessing anti-mitotic and anti-
proliferative activity. In the biosynthesis of curacin A, the N-terminal domain of the CurF …

HCHL (hydroxycinnamoyl-CoA hydratase–lyase) catalyses the biotransformation of feruloyl-
CoA to acetyl-CoA and the important flavour–fragrance compound vanillin (4-hydroxy-3 …

Approximately 50 naturally occurring carbapenem β‐lactam antibiotics are known. All but
one of these have been isolated from Streptomyces species and are disubstituted structural …

Studies on the substrate selectivity of recombinant ferrous-iron-and 2-oxoglutarate-
dependent proline hydroxylases (PHs) reveal that they can catalyse the production of …

The biocatalytic versatility of wildtype and engineered carboxymethylproline synthases
(CMPSs) is demonstrated by the preparation of functionalized 5-carboxymethylproline …