Herpes simplex virus 1 deregulation of host microRNAs
Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and
mechanisms, apparently far beyond the classical understanding of gene repression in …
mechanisms, apparently far beyond the classical understanding of gene repression in …
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection
T Alandijany, APE Roberts, KL Conn, C Loney… - PLoS …, 2018 - journals.plos.org
Detection of viral nucleic acids plays a critical role in the induction of intracellular host
immune defences. However, the temporal recruitment of immune regulators to infecting viral …
immune defences. However, the temporal recruitment of immune regulators to infecting viral …
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6
Y Lu, JH Stuart, C Talbot-Cooper… - Proceedings of the …, 2019 - National Acad Sciences
Interferons (IFNs) represent an important host defense against viruses. Type I IFNs induce
JAK-STAT signaling and expression of IFN-stimulated genes (ISGs), which mediate antiviral …
JAK-STAT signaling and expression of IFN-stimulated genes (ISGs), which mediate antiviral …
Human cytomegalovirus immediate-early 1 protein rewires upstream STAT3 to downstream STAT1 signaling switching an IL6-type to an IFNγ-like response
T Harwardt, S Lukas, M Zenger, T Reitberger… - PLoS …, 2016 - journals.plos.org
The human cytomegalovirus (hCMV) major immediate-early 1 protein (IE1) is best known for
activating transcription to facilitate viral replication. Here we present transcriptome data …
activating transcription to facilitate viral replication. Here we present transcriptome data …
Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1
C Paulus, T Harwardt, B Walter, A Marxreiter… - PLoS …, 2020 - journals.plos.org
Promyelocytic leukemia (PML) bodies are nuclear organelles implicated in intrinsic and
innate antiviral defense. The eponymous PML proteins, central to the self-organization of …
innate antiviral defense. The eponymous PML proteins, central to the self-organization of …
Human cytomegalovirus long non-coding RNA1. 2 suppresses extracellular release of the pro-inflammatory cytokine IL-6 by blocking NF-κB activation
Long non-coding RNAs (lncRNAs) are transcripts of> 200 nucleotides that are not translated
into functional proteins. Cellular lncRNAs have been shown to act as regulators by …
into functional proteins. Cellular lncRNAs have been shown to act as regulators by …
Assembly of Epstein-Barr virus capsid in promyelocytic leukemia nuclear bodies
WH Wang, CW Kuo, LK Chang, CC Hung… - Journal of …, 2015 - Am Soc Microbiol
ABSTRACT The Epstein-Barr virus (EBV) capsid contains a major capsid protein, VCA; two
minor capsid proteins, BDLF1 and BORF1; and a small capsid protein, BFRF3. During the …
minor capsid proteins, BDLF1 and BORF1; and a small capsid protein, BFRF3. During the …
Viral ubiquitin ligase stimulates selective host microRNA expression by targeting ZEB transcriptional repressors
Infection with herpes simplex virus-1 (HSV-1) brings numerous changes in cellular gene
expression. Levels of most host mRNAs are reduced, limiting synthesis of host proteins …
expression. Levels of most host mRNAs are reduced, limiting synthesis of host proteins …
Human cytomegalovirus RNA2. 7 is required for upregulating multiple cellular genes to promote cell motility and viral spread late in lytic infection
B Lau, K Kerr, S Camiolo, K Nightingale, Q Gu… - Journal of …, 2021 - Am Soc Microbiol
Long noncoding RNAs (lncRNAs) are frequently associated with broad modulation of gene
expression and thus provide the cell with the ability to synchronize entire metabolic …
expression and thus provide the cell with the ability to synchronize entire metabolic …
Stimulation of the replication of ICP0-null mutant herpes simplex virus 1 and pp71-deficient human cytomegalovirus by epstein-barr virus tegument protein BNRF1
Y Lu, A Orr, RD Everett - Journal of Virology, 2016 - Am Soc Microbiol
It is now well established that several cellular proteins that are components of promyelocytic
leukemia nuclear bodies (PML NBs, also known as ND10) have restrictive effects on …
leukemia nuclear bodies (PML NBs, also known as ND10) have restrictive effects on …