Transcriptomic and proteomic of gastrocnemius muscle in peripheral artery disease
Background: Few effective therapies exist to improve lower extremity muscle pathology and
mobility loss due to peripheral artery disease (PAD), in part because mechanisms …
mobility loss due to peripheral artery disease (PAD), in part because mechanisms …
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET
DC Kanellis, A Zisi, Z Skrott, B Lemmens… - Cell Death & …, 2023 - nature.com
Drug repurposing is a versatile strategy to improve current therapies. Disulfiram has long
been used in the treatment of alcohol dependency and multiple clinical trials to evaluate its …
been used in the treatment of alcohol dependency and multiple clinical trials to evaluate its …
CDK7/CDK9 mediates transcriptional activation to prime paraptosis in cancer cells
Background Paraptosis is a programmed cell death characterized by cytoplasmic
vacuolation, which has been explored as an alternative method for cancer treatment and is …
vacuolation, which has been explored as an alternative method for cancer treatment and is …
Inhibition of EIF2α Dephosphorylation Decreases Cell Viability and Synergizes with Standard-of-Care Chemotherapeutics in Head and Neck Squamous Cell …
AM Cyran, F Kleinegger, N Nass, M Naumann… - Cancers, 2023 - mdpi.com
Simple Summary Head and neck squamous cell carcinoma (HNSCC) arises in the mucosal
membranes in the head and neck and constitutes 3.9% of new cancer cases annually. Its …
membranes in the head and neck and constitutes 3.9% of new cancer cases annually. Its …
[图书][B] Computational and Chemical Approaches to Drug Repurposing
X Li - 2023 - search.proquest.com
Drug repurposing, which entails discovering novel therapeutic applications for already
existing drugs, provides numerous benefits compared to conventional drug discovery …
existing drugs, provides numerous benefits compared to conventional drug discovery …