Otolith biochemistry—a review

ORB Thomas, SE Swearer - Reviews in Fisheries Science & …, 2019 - Taylor & Francis
Otoliths are bioinorganic minerals within the inner ear of all bony fishes. They grow
incrementally, laying down alternating protein-rich and mineral-rich bands daily …

Mechanisms of otoconia and otolith development

YW Lundberg, Y Xu, KD Thiessen… - Developmental …, 2015 - Wiley Online Library
Background: Otoconia are bio‐crystals that couple mechanic forces to the sensory hair cells
in the utricle and saccule, a process essential for us to sense linear acceleration and gravity …

The role of motile cilia in the development and physiology of the nervous system

C Ringers, EW Olstad… - … Transactions of the …, 2020 - royalsocietypublishing.org
Motile cilia are miniature, whip-like organelles whose beating generates a directional fluid
flow. The flow generated by ciliated epithelia is a subject of great interest, as defective ciliary …

[HTML][HTML] Development of the inner ear

TT Whitfield - Current opinion in genetics & development, 2015 - Elsevier
The vertebrate inner ear is a sensory organ of exquisite design and sensitivity. It responds to
sound, gravity and movement, serving both auditory (hearing) and vestibular (balance) …

Genetic and epigenetic evidence for nonestrogenic disruption of otolith development by bisphenol a in zebrafish

M Yuan, C Zeng, H Lu, Y Yue, T Sun… - Environmental …, 2023 - ACS Publications
Bisphenol A (BPA) is a well-known endocrine-disrupting chemical (EDC) that has estrogenic
activities. In addition to disrupting reproductive development and function via estrogenic …

Zebrafish as a model for human ciliopathies

Z Song, X Zhang, S Jia, PC Yelick, C Zhao - Journal of Genetics and …, 2016 - Elsevier
Cilia, microtubule-based structures found on the surface of almost all vertebrate cells, play
an array of diverse biological functions. Abnormal ciliary axonemal structure and function …

NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis

M Liu, W Zhang, M Li, J Feng, W Kuang, X Chen… - Cell Research, 2021 - nature.com
Primary cilia extending from mother centrioles are essential for vertebrate development and
homeostasis maintenance. Centriolar coiled-coil protein 110 (CP110) has been reported to …

[HTML][HTML] Sculpting the labyrinth: morphogenesis of the developing inner ear

B Alsina, TT Whitfield - Seminars in Cell & Developmental Biology, 2017 - Elsevier
The vertebrate inner ear is a precision sensory organ, acting as both a microphone to
receive sound and an accelerometer to detect gravity and motion. It consists of a series of …

Mutations in GAS8, a Gene Encoding a Nexin‐Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization

L Jeanson, L Thomas, B Copin, A Coste… - Human …, 2016 - Wiley Online Library
Primary ciliary dyskinesia (PCD) is an autosomal recessive disease characterized by
chronic respiratory infections of the upper and lower airways, hypofertility, and, in …

Visualizing multiciliated cells in the zebrafish

HM Wesselman, AE Gatz, RA Wingert - Methods in Cell Biology, 2023 - Elsevier
Ciliated cells serve vital functions in the body ranging from mechano-and chemo-sensing to
fluid propulsion. Specialized cells with bundles dozens to hundreds of motile cilia known as …