Acquired immunodeficiency syndrome (AIDS), a serious public health concern worldwide, is
predominantly caused by human immunodeficiency virus type 1 (HIV-1). More than 30 drugs …

The acquisition of m7G-cap-binding proteins is now recognized as a major variable driving
the form and function of host RNAs. This manuscript compares the 5′-cap-RNA binding …

ABSTRACT HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no
desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” …

Total HIV DNA is a standard marker to monitor the HIV reservoir in people living with HIV.
We investigated HIV DNA quantification accuracy by a real-time PCR kit (qPCR) and digital …

Our understanding of HIV infection has greatly advanced since the discovery of the virus in
1983. Treatment options have improved the quality of life of people living with HIV/AIDS …

Co-infection or superinfection of the host by two or more virus species is a common event,
potentially leading to viral interference, viral synergy, or neutral interaction. The …

Background Patients with immunodeficiency virus-1 (HIV-1) infection are challenging to be
cured completely due to the existence of HIV-1 latency reservoirs. However, the knowledge …

Bromodomain-containing protein 4 (BRD4) inhibitors have been proven to be a promising
option for anti-HIV-1 latency therapeutics. We herein describe the design, synthesis, and anti …

With nearly 38 million of people worldwide living with HIV-1 and no definitive cure available
after almost 40 years of research, AIDS is still a major global public health issue. Modern …

HIV latent infection may be associated with disrupted viral RNA sensing, interferon (IFN)
signaling, and/or IFN stimulating genes (ISG) activation. Here, we evaluated the use of …