Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Hereditary hemochromatosis (HH) is one of the most common genetic disorders among
persons of northern European descent. There have been recent advances in the diagnosis …

Hemochromatosis | New England Journal of Medicine Skip to main content The New England
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Hereditary iron overload includes several disorders characterized by iron accumulation in
tissues, organs, or even single cells or subcellular compartments. They are determined by …

Background Iron overload syndromes encompass a wide range of hereditary and acquired
conditions. Major developments in the field of genetics and the discovery of hepcidin as a …

Iron is implicated in the pathogenesis of a number of human liver diseases. Hereditary
hemochromatosis is the classical example of a liver disease caused by iron, but iron is …

Despite several decades of study, whether iron is involved in the development of
atherosclerosis remains a controversial and unresolved issue. Here, we focus on the up-to …

Iron overload disorders represent an important class of human diseases. Of the primary iron
overload conditions, by far the most common and best studied is HFE-related …

Molecular genetic testing for hereditary hemochromatosis (HH) is recognized as a reference
test to confirm the diagnosis of suspected HH or to predict its risk. The vast majority …

Iron overload (hemochromatosis) can cause serious, symptomatic disease that is
preventable if detected early and managed appropriately. The leading cause of …