The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …

Precise control of organ size is crucial during animal development and regeneration. In
Drosophila and mammals, studies over the past decade have uncovered a critical role for …

The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …

The Hippo pathway has emerged as a conserved signaling pathway that is essential for the
proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms …

The Hippo signaling pathway is gaining recognition as an important player in both organ
size control and tumorigenesis, which are physiological and pathological processes that …

The Hippo-Yes-associated protein (YAP) signaling network plays a central role as an
integrator of signals that control cellular proliferation and differentiation. The past several …

The Yes-associated protein (YAP) is a transcription coactivator that plays a crucial role in
organ size control by promoting cell proliferation and inhibiting apoptosis. The Hippo tumor …

The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by
phosphorylating them for cytoplasmic sequestration or degradation. In this report, we …