• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Off-label use of medication may be presented in these guidelines if a sufficient level of
evidence shows that it can be considered medically appropriate to a given condition and if …

Although the administration of fluid is the first treatment considered in almost all cases of
circulatory failure, this therapeutic option poses two essential problems: the increase in …

Background During general anaesthesia for noncardiac surgery, there remain knowledge
gaps regarding the effect of goal-directed haemodynamic therapy on patient-centred …

Despite a large body of evidence, the implementation of guidelines on hemodynamic
optimization and goal-directed therapy remains limited in daily routine practice. To …

Background Postoperative complications impact on early and long-term patients' outcome.
Appropriate perioperative fluid management is pivotal in this context; however, the most …

Introduction ERAS pathway has been proposed as the standard of care in elective
abdominal surgery. Guidelines on ERAS in emergency surgery have been recently …

Objective. Accurate haemodynamic monitoring is the cornerstone in the management of
critically ill patients. It guides the optimization of tissue and organ perfusion in order to …

(1) Background: Whether goal-directed fluid therapy (GDFT) provides any outcome benefit
as compared to non-goal-directed fluid therapy (N-GDFT) in elective abdominal …

Background Goal-directed therapy (GDT) aims to assure tissue perfusion, by optimizing
doses and timing of fluids, inotropes, and vasopressors, through monitoring of cardiac output …