The human epidermal growth factor receptor (EGFR) of HER/ErbB receptor tyrosine kinase
family mediates a broad spectrum of cellular responses transducing biochemical signals via …

Specific helix–helix interactions between the single-span transmembrane domains of
receptor tyrosine kinases are believed to be important for their lateral dimerization and …

The epidermal growth factor receptor (EGFR) family is an important class of receptor tyrosine
kinases, mediating a variety of cellular responses in normal biological processes and in …

Abstract Latent membrane protein 1 (LMP1) is a gene product of the Epstein-Barr virus
(EBV), a widely spread virus present in 90–95% of the world's population. EBV can lead to …

Genome of the hepatitis C virus (HCV) contains a long open reading frame encoding a
polyprotein that is cleaved into 10 proteins. Recently, a novel, so called “ARFP/F”, or “core+ …

In the case of soluble proteins, chemical shift mapping is used to identify the intermolecular
interfaces when the NOE-based calculations of spatial structure of the molecular assembly …

Chemokine receptors form a major sub-family of G protein-coupled receptors (GPCRs) and
they are involved in a number of cellular and physiological processes related to our immune …

Receptor tyrosine kinases (RTKs) play an important role in intercellular signal transduction
through the plasma membrane. RTKs are integral membrane proteins activated upon lateral …

In this thesis I have investigated the molecular signatures of receptor activation, using the β1-
adrenergic receptor (β1AR) as a prototypical class A G-protein coupled receptor (GPCR). I …

Рецепторные тирозинкиназы интегральные мембранные белки, которые
активируются при латеральной гомо-или гетеродимеризации, осуществляемой с …