Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is
currently the standard intervention. However, the reperfusion may lead to further myocardial …

Oxidative stress plays a key role in many physiological and pathological conditions. The
intracellular oxidative homeostasis is tightly regulated by the reactive oxygen species …

Reactive oxygen species (ROS)-induced cardiac cell injury via expression changes of
multiple genes plays a critical role in the pathogenesis of numerous heart diseases …

Reperfusion therapy is widely used to treat acute myocardial infarction. However, its efficacy
is limited by myocardial ischemia-reperfusion injury (MIRI), which occurs paradoxically due …

The role of oxidative stress in ischaemic heart disease has been thoroughly investigated in
humans. Increased levels of ROS (reactive oxygen species) and RNS (reactive nitrogen …

Free radicals are highly reactive molecules produced in the cell either as part of, or as end-
products of, biochemical reactions that have crucial roles in the homeostasis of the …

Abstract Aims: Ischemia/reperfusion (I/R) injury is a common clinical problem. Although the
pathophysiological mechanisms underlying I/R injury are unclear, oxidative damage is …

Background Ischemia/reperfusion (I/R) injury causes overproduction of reactive oxygen
species, which are the major culprits of oxidative stress that leads to inflammation …

Prostaglandin F2α (PGF2α), a foremost stable vasoactive cyclooxygenase (COX)‐catalyzed
prostaglandin, regulates a number of key physiological functions such as luteolysis, ovarian …

Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality
worldwide. The exploration of new biomarkers with high sensitivity and specificity for early …