We sought to define whether there are intrinsic molecular subtypes of high-grade bladder
cancer. Consensus clustering performed on gene expression data from a meta-dataset of …

Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation reaction of
nicotinamide, using S-adenosyl-L-methionine as the methyl donor. Enzyme overexpression …

Chemotherapy and targeted therapy can significantly improve survival rates in cancer, but
multiple drug resistance (MDR) limits the efficacy of these approaches. Understanding the …

Muscle-invasive bladder carcinoma (MIBC) constitutes a heterogeneous group of tumors
with a poor outcome. Molecular stratification of MIBC may identify clinically relevant tumor …

Current clinical judgment in bladder cancer (BC) relies primarily on pathological stage and
grade. We investigated whether a molecular classification of tumor cell differentiation, based …

Purpose: Hypoxia modification improves overall survival in muscle-invasive bladder cancer
patients who undergo radiotherapy. There is evidence that hypoxic tumors benefit most from …

Abstract S100A8/A9, a proinflammatory protein, is upregulated in inflammatory diseases,
and also has a tumor-promoting activity by the recruitment of myeloid cells and tumor cell …

More than 160,000 people are expected to die from invasive urothelial carcinoma (iUC) this
year worldwide. Research in relevant animal models is essential to improving iUC …

EGFR is a potential therapeutic target for treating bladder cancer, but has not been
approved for clinical use yet. Metformin is a widely used antidiabetic drug and has …

Urothelial carcinoma (UC), also referred to as transitional cell carcinoma (TCC), is the most
common bladder malignancy in both human and canine populations. In human UC …