Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has
a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both …

Existing drug delivery methods have not led to a significant increase in survival for patients
with malignant primary brain tumors. While the combination of conventional therapies …

Biodegradable nanoparticles formulated from poly (d, l-lactide-co-glycolide)(PLGA) have
been extensively investigated for sustained and targeted/localized delivery of different …

The blood-brain barrier (BBB) contributes to brain homeostasis by protecting the brain from
potentially harmful endogenous and exogenous substances. BBB active drug efflux …

PURPOSE Effective therapies are needed for the treatment of patients with human
epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer (MBC) with …

Resistance to drug treatment is an important hurdle in the therapy of many brain disorders,
including brain cancer, epilepsy, schizophrenia, depression and infection of the brain with …

Despite scientific advances in understanding the causes and treatment of human
malignancy, a persistent challenge facing basic and clinical investigators is how to …

ATP Binding Cassette (ABC) transporters form a special family of membrane proteins,
characterized by homologous ATP-binding, and large, multispanning transmembrane …

The blood–brain barrier (BBB) serves as a protective mechanism for the brain by preventing
entry of potentially harmful substances from free access to the central nervous system …

The blood-brain barrier (BBB) and blood-cerebrospinal fluid (BCSF) barriers are critical
determinants of CNS homeostasis. Additionally, the BBB and BCSF barriers are formidable …