Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of
synaptic transmission and plasticity. They are synthetized “on demand” following …

Diverse inhibitory neurons in the mammalian brain shape circuit connectivity and dynamics
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …

The graceful, purposeful motion of our body is an engineering feat that remains unparalleled
in robotic devices using advanced artificial intelligence. Much of the information required for …

This work considers a class of canonical neural networks comprising rate coding models,
wherein neural activity and plasticity minimise a common cost function—and plasticity is …

Inhibitory neurons, although relatively few in number, exert powerful control over brain
circuits. They stabilize network activity in the face of strong feedback excitation and actively …

Highlights•The three-factor framework describes various learning rules in a unified
way.•Third factors can encode reward, attention, summary statistics, or supervised …

Paired Associative Stimulation (PAS) has come to prominence as a potential therapeutic
intervention for the treatment of brain injury/disease, and as an experimental method with …

The corticostriatal pathway that carries sensory, motor, and limbic information to the striatum
plays a critical role in motor control, action selection, and reward. Dysfunction of this …

Recent studies have identified impairments in neural induction and in striatal and cortical
neurogenesis in Huntington's disease (HD) knock-in mouse models and associated …

While the plasticity of excitatory synaptic connections in the brain has been widely studied,
the plasticity of inhibitory connections is much less understood. Here, we present recent …