Biofilms are surface-associated, multicellular communities of bacteria. Once established,
they are extremely difficult to eradicate by antimicrobial treatment. It has been demonstrated …

There has been considerable investigation of host-microbial interactions in patients with
chronic rhinosinusitis (CRS) in hopes of elucidating mechanisms of disease and better …

Biofilm formation on indwelling medical devices represents an exclusive evasion
mechanism for many pathogenic bacteria to establish chronic infections. Staphylococcus …

We previously observed that the human bitter taste receptor T2R38 is an important
component of upper respiratory innate defense because it detects acyl homoserine lactone …

Periprosthetic joint infection (PJI) remains a devastating complication after total joint
arthroplasty. Bacteria involved in these infections are notorious for adhering to foreign …

Pseudomonas aeruginosa biofilms contribute heavily to chronic lung infection in cystic
fibrosis patients, leading to morbidity and mortality. Nitric oxide (NO) has been shown to …

Ventricular shunts are the most common neurosurgical procedure performed in the United
States. This hydrocephalus treatment is often complicated by infection of the device with …

Recurrent respiratory tract infections (RRTIs) are very common in children and a major
challenge for pediatricians. In the last few years, bacterial biofilms have been linked to …

Although frequently used, venous catheters are often associated with serious complications
such as infection and thrombosis. Lock solution therapies are clinically used to deter these …

Implantable medical device-related infections with biofilms have become a significant
challenge in clinics. Based on the potential bacteria biofilm dispersing effect of nitric oxide …