Somatic rearrangements resulting in genomic structural variation drive malignant
phenotypes by altering the expression or function of cancer genes. Pan-cancer studies have …

One of the most curious findings emerged from genome-wide studies over the last decade
was that genetic mosaicism is a dominant feature of human ageing genomes. The clonal …

Somatic copy number alterations (SCNAs) are a pervasive trait of human cancers that
contributes to tumorigenesis by affecting the dosage of multiple genes at the same time. In …

Simple Summary Copy number alterations (CNAs) occur due to changes to DNA structure
that lead to the gain/amplification or loss/deletion of copies of DNA sections from a normal …

Analysis of cancer genomes has shown that a large fraction of chromosomal changes
originate from catastrophic events including whole-genome duplication, chromothripsis …

Adaptive mutations can cause drug resistance in cancers and pathogens, and increase the
tolerance of agricultural pests and diseases to chemical treatment. When and how adaptive …

Cancer research has recently benefitted from the integration of evolutionary theory to study
somatic genome evolution during tumor development. Here, we explore how investigating …