A pan-cancer organoid platform for precision medicine

BM Larsen, M Kannan, LF Langer, BD Leibowitz… - Cell reports, 2021 - cell.com
Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer
biology and develop novel precision medicine therapeutics. However, utilizing TOs for …

Dynamic Co-evolution of cancer cells and cancer-associated fibroblasts: Role in right-and left-sided colon cancer progression and its clinical relevance

SS Ahmad Zawawi, M Musa - Biology, 2022 - mdpi.com
Simple Summary The versatile crosstalk between cancer cells and cancer-associated
fibroblasts (CAFs) of the tumour microenvironment (TME) drives colorectal carcinogenesis …

CAF variants control the tumor-immune microenvironment and predict skin cancer malignancy

A Forsthuber, A Korosec, T Jacob, B Aschenbrenner… - bioRxiv, 2023 - biorxiv.org
Cancer-associated fibroblasts (CAFs) play a key role in cancer progression and treatment
outcome. Here, we elucidate the yet unresolved intra-tumoral CAF variety in three skin …