T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …

As early T cell precursors transition from multipotentiality to T lineage commitment, they
change expression of multiple transcription factors. It is unclear whether individual …

Innate lymphoid cells (ILCs) are critical effectors of innate immunity and inflammation, whose
development and activation pathways make for attractive therapeutic targets. However …

Studies of human lung development have focused on epithelial and mesenchymal cell types
and function, but much less is known about the developing lung immune cells, even though …

Organoid-based models of murine and human innate lymphoid cell precursor (ILCP)
maturation are presented. First, murine intestinal and pulmonary organoids are harnessed to …

Innate lymphoid cells (ILCs) are well-characterized immune cells that play key roles in host
defense and tissue homeostasis. Yet, how the three-dimensional (3D) genome organization …

The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a
previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to …

Since the start of COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), more than 6 million people have lost their lives worldwide …

Innate lymphoid cells (ILCs) are heterogeneous innate immune cells which participate in
host defense, mucosal repair and immunopathology by producing effector cytokines …