Joint pain is the hallmark symptom of osteoarthritis (OA) and the main reason for patients to
seek medical assistance. OA pain greatly contributes to functional limitations of joints and …

The mechanisms underlying the pathogenesis of rheumatoid arthritis (RA) involve different
components of the immune system. In subjects with genetic predisposition to develop RA, a …

Summary The interleukin 1 (IL-1) pathway signals through IL-1 receptor type 1 (IL-1R1) and
emerges as a central mediator for systemic inflammation. Aberrant IL-1 signaling leads to a …

Background Wear particles-induced osteolysis is a major long-term complication after total
joint arthroplasty. Up to now, there is no effective treatment for wear particles-induced …

The term osteoimmunology describes an interdisciplinary research field that links the
investigation of osteology (bone cells) with immunology. The crosstalk between innate and …

Bone homeostasis is a dynamic equilibrium state of bone formation and absorption,
ensuring skeletal development and repair. Bone immunity encompasses all aspects of the …

Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) are
considered the same disease, but a common approach for diagnosis and management is …

Cytokines are an important set of proteins regulating bone homeostasis. In inflammation
induced bone resorption, cytokines, such as RANKL, TNF-α, M-CSF, are indispensable for …

The presence of anti-citrullinated protein autoantibodies (ACPA) is a hallmark feature of
rheumatoid arthritis (RA), which causes chronic joint destruction and systemic inflammation …

Summary The interleukin 6 (IL6) signaling pathway plays pleiotropic roles in regulating the
inflammatory milieu that contributes to arthritis development. Here, we show that activation of …