The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

As brutally demonstrated by the COVID-19 pandemic, an effective immune system is
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …

Eosinophilia and eosinophil activation are recurrent features in various reactive states and
certain hematologic malignancies. In patients with hypereosinophilia (HE), HE‐induced …

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …

Fundamental insight gained over the last decades led to the discovery of cytokines as
pivotal drivers of inflammatory diseases such as rheumatoid arthritis, psoriasis/psoriasis …

Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …

INTRODUCTION Studies of monogenic diseases have uncovered the importance of immune
pathways in human tissue-specific immunity and antimicrobial defense. In particular, human …

Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …

The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …

Autoimmunity and immunodeficiency were previously considered to be mutually exclusive
conditions; however, increased understanding of the complex immune regulatory and …