Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …

Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite
30+ years of intense investigation, the field lacks consensus regarding the etiology and …

Omega-3 polyunsaturated fatty acids (n‐3-PUFAs), mainly eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA), may improve or prevent some psychiatric and …

Purinergic signalling appears to play important roles in neurodegeneration, neuroprotection
and neuroregeneration. Initially there is a brief summary of the background of purinergic …

Defects in neuronal activity of the entorhinal cortex (EC) are suspected to underlie the
symptoms of Alzheimer's disease (AD). Whereas neuroprotective effects of …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
brain deposition of senile (neuritic) plaques containing amyloid-β, neurofibrillary tangles …

There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the
brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic …

Background and purpose: Neurological diseases and injuries to the nervous system may
cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would …

Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid (PUFA) in the brain
and a structural component of neuronal membranes. Changes in DHA content of neuronal …

Evolution of the high order brain function in humans can be attributed to intake of poly
unsaturated fatty acids (PUFAs) of which the ω-3 fatty acid, docosahexaenoic acid (DHA) …