Obesity has become a serious public health problem and a major risk factor for the
development of illnesses, such as insulin resistance and hypertension. Human homeostatic …

Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …

Hormesis in aging is represented by mild stress-induced stimulation of protective
mechanisms in cells and organisms resulting in biologically beneficial effects. Single or …

Resetting the circadian clock leads to well being and increased life span, whereas clock
disruption is associated with aging and morbidity. Increased longevity and improved health …

Background Traumatic brain injury (TBI) initiates a complex series of neurochemical and
signaling changes that lead to pathological events including neuronal hyperactivity …

Increased lifespans have led to population aging and brought attention to healthcare
concerns associated with old age. A growing body of preclinical and clinical research has …

Increased longevity and improved health can be achieved in mammals by two feeding
regimens, caloric restriction (CR), which limits the amount of daily calorie intake, and …

Depression is a common neurological disease that seriously affects human health. There
are many hypotheses about the pathogenesis of depression, and the most widely …

Young male Fischer-344 rats were fed a diet containing 2% blueberry (BB) extract or control
diet for at least 8 weeks and then received bilateral hippocampal injections of kainic acid …

Aging at the molecular level is characterized by the progressive accumulation of molecular
damage. The sources of damage act randomly through environmental and metabolically …