Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that
hypertension is the result of many factors that interact to raise blood pressure and cause end …

Abstract Purpose of Review Mechanisms facilitating progression of hypertension via cross
stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed …

Abstract The (pro) renin receptor ((P) RR) was first identified as a single-transmembrane
receptor in human kidneys and initially attracted attention owing to its potential role as a …

A healthy pregnancy outcome depends on the activation of the renin-angiotensin-
aldosterone system (RAAS) as a regulated, integrated response to the growing demands of …

The intrarenal renin–angiotensin system is critical for the regulation of tubule sodium
reabsorption, renal haemodynamics and blood pressure. The excretion of renin in urine can …

Cardiovascular disease is a pathology that exhibits well-researched biological sex
differences, making it possible for physicians to tailor preventative and therapeutic …

Emerging evidence has demonstrated that (pro) renin receptor (PRR)-mediated activation of
intrarenal renin-angiotensin system (RAS) plays an essential role in renal handling of Na+ …

Rationale: Cleavage of the extracellular domain of the PRR ([pro] renin receptor) yields a
soluble fragment (sPRR). Although changes in plasma sPRR levels have been reported in …

Abstract (Pro) renin receptor (PRR), along with its soluble form, sPRR, functions not only as
a crucial activator of the local renin-angiotensin system but also engages with and activates …

Abstract The (pro) renin receptor [(P) RR, Atp6ap2] was initially discovered as a membrane-
bound binding partner of prorenin and renin. A soluble (P) RR has additional paracrine …