Mutations within the FMS-like tyrosine kinase 3 (FLT3) gene on chromosome 13q12 have
been detected in up to 35% of acute myeloid leukemia (AML) patients and represent one of …

Abstract Heat shock protein 90 (HSP90) is a ubiquitously expressed chaperone that is
involved in the posttranslational folding and stability of proteins. Inhibition at the NH2 …

Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and
children, yet significant numbers of patients relapse and die of disease. In this study, we …

Hsp90 is a ubiquitous chaperone with important roles in the organization and maturation of
client proteins that are involved in the progression and survival of cancer cells. Multiple …

Hsp90 is a chaperone protein that interacts with client proteins that are known to be in the
cell cycle, signaling and chromatin-remodeling pathways. Hsp90 inhibitors act additively or …

Internal tandem duplication (ITD) of the fms-like tyrosine kinase 3 (FLT3) gene is a gain-of-
function mutation common in acute myeloid leukaemia (AML). It is associated with inferior …

Abstract Heat shock protein 90 (Hsp90) is constitutively expressed at 2‑10‑fold higher levels
in tumor cells compared to normal cells, suggesting that it may be critically important for …

FMS-like tyrosine kinase 3 (FLT3) is mutated in approximately 30% of acute myeloid
leukemia (AML) patients. The presence of FLT3-ITD (internal tandem duplication, 20–25%) …

An appealing therapeutic target for AML is constitutively activated, mutant FLT3, which is
expressed in a subpopulation of AML patients and is generally a poor prognostic indicator in …

Abstract Mutant Fms-Like Tyrosine kinase-3 (FLT3), which is expressed in the leukemic cells
of a subpopulation of acute myeloid leukemia (AML) patients, represents an attractive target …