The urothelium: life in a liquid environment
The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …
forms a high-resistance but adaptable barrier that surveils its mechanochemical …
Enhanced RAGE expression and excess reactive-oxygen species production mediates Rho kinase-dependent detrusor overactivity after methylglyoxal exposure
Methylglyoxal (MGO) is a highly reactive dicarbonyl compound implicated in diabetes-
associated diseases. In vascular tissues, MGO induces the formation of advanced glycation …
associated diseases. In vascular tissues, MGO induces the formation of advanced glycation …
Activation of Piezo1 or TRPV2 channels inhibits human ureteral contractions via NO release from the mucosa
J Liu, C Wang, W Wang, N Ding, J Liu, H Liu… - Frontiers in …, 2024 - frontiersin.org
We aimed to investigate the expression and motor modulatory roles of several mechano-
sensitive channels (MSCs) in human ureter. Human proximal ureters were obtained from …
sensitive channels (MSCs) in human ureter. Human proximal ureters were obtained from …
β3 Relaxant Effect in Human Bladder Involves Cystathionine γ-Lyase-Derived Urothelial Hydrogen Sulfide
E Mitidieri, A Pecoraro, E Esposito, V Brancaleone… - Antioxidants, 2022 - mdpi.com
It is now well established that the urothelium does not act as a passive barrier but
contributes to bladder homeostasis by releasing several signaling molecules in response to …
contributes to bladder homeostasis by releasing several signaling molecules in response to …
Emerging therapies for overactive bladder: preclinical, phase I and phase II studies
S Gibson, P Ellsworth - Expert Opinion on Investigational Drugs, 2024 - Taylor & Francis
Introduction Overactive bladder syndrome is a common chronic condition with a significant
impact on quality of life and economic burden. Persistence with pharmacologic therapy has …
impact on quality of life and economic burden. Persistence with pharmacologic therapy has …
[HTML][HTML] Constitutively active HCN channels constrain detrusor excitability and modulate evoked contractions of human bladder
Objective: Expression of Hyperpolarization-activated cyclic nucleotide-gated (HCN)
channels is reported in bladder, but the functional role remains unsettled. Here, we …
channels is reported in bladder, but the functional role remains unsettled. Here, we …
Impairment of urinary bladder mechanical properties in rat model of type 2 diabetes
IB Philyppov, GV Sotkis, AO Danshyna… - Neurourology and …, 2022 - Wiley Online Library
Aims The urinary bladder is a mechanosensitive organ that accumulates, stores, and expels
considerable amounts of fluid. While the neuronal bladder control via the CNS is well …
considerable amounts of fluid. While the neuronal bladder control via the CNS is well …
[HTML][HTML] Bladder attack: transient bladder ischemia leads to a reversible decrease in detrusor compliance
AT Tracey, UA Anele, RA Vince, JE Speich… - Translational …, 2019 - ncbi.nlm.nih.gov
Background The deleterious effects of chronic ischemia on bladder function have been
extensively studied; however, evaluation and characterization of the effects of acute …
extensively studied; however, evaluation and characterization of the effects of acute …
Age-and Urothelium-related Changes in Hydrogen Sulfide-induced Responses in Mouse Bladder
F Aydinoglu, T Toyran, N Ogulener - Journal of Physiological …, 2024 - journals.lww.com
The alterations in bladder function are associated with aging. Hydrogen sulfide (H 2 S) is a
gaseous neurotransmitter that is synthesized in the urinary bladder and is suggested to …
gaseous neurotransmitter that is synthesized in the urinary bladder and is suggested to …