Chaperone-mediated autophagy (CMA) was the first studied process that indicated that
degradation of intracellular components by the lysosome can be selective—a concept that is …

Neurodegenerative diseases (NDs) are one of the major health threats to human
characterized by selective and progressive neuronal loss. The mechanisms of NDs are still …

The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-
long production of blood cells. This process requires major molecular adaptations to allow …

Neuroinflammation is a pathological change that is involved in the progression of
Parkinson's disease. Dysfunction of chaperone-mediated autophagy (CMA) has …

Accumulation of oxidative stress is highly intertwined with aging process and contributes to
aging‐related diseases, such as neurodegenerative diseases. Deciphering the molecular …

Endoplasmic reticulum (ER) and lysosomes coordinate a network of key cellular processes
including unfolded protein response (UPR) and autophagy in response to stress. How ER …

Cellular quality control systems have gained much attention in recent decades. Among
these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, with
current treatment being mainly symptomatic and often accompanied by serious side effects …

Parkinson disease (PD) is the second most common neurodegenerative disease after
Alzheimer disease. Although PD has a relatively narrow clinical phenotype, it has become …

Background The development of diabetes vascular calcification (VC) is tightly associated
with the inhibition of vascular smooth muscle cell (VSMC) autophagy. Previously, our team …