Successful in vivo infection following pathogen entry requires the evasion and subversion of
multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune …

Abstract α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in
SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes …

Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …

Rationale: Chronic obstructive pulmonary disease (COPD) exacerbations are associated
with virus (mostly rhinovirus) and bacterial infections, but it is not known whether rhinovirus …

Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of liver disorders, from fatty
liver to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma …

Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene, whereas chronic
obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly …

The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the
lack of preclinical data and so most of the assumptions made about NE inhibitor potential …

Cystic fibrosis (CF) lung disease is an inherited condition with an incidence rate of
approximately 1 in 2500 new born babies. CF is characterized as chronic infection of the …

Chronic inflammatory lung diseases such as cystic fibrosis and emphysema are
characterized by higher‐than‐normal levels of pulmonary proteases. While these enzymes …

The arrival of cystic fibrosis transmembrane conductance regulator (CFTR) modulators as a
new class of treatment for cystic fibrosis (CF) in 2012 represented a pivotal advance in …