The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …

Pluripotent embryonic stem cells (ESCs) are considered to have open and accessible
chromatin relative to differentiated cells. However, as many studies supporting these …

Transposable elements (TEs) make up a majority of a typical eukaryote's genome, and
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …

Background Association of chromatin with lamin proteins at the nuclear periphery has
emerged as a potential mechanism to coordinate cell type-specific gene expression and …

Cell fate decisions are governed by sequence-specific transcription factors (TFs) that act in
small populations of cells within developing embryos. To understand their functions in vivo, it …

Transposable elements (TEs) regulate diverse biological processes, from early development
to cancer. Expression of young TEs is difficult to measure with next-generation, single-cell …

Functional changes in spatial genome organization during human development are poorly
understood. Here we report a comprehensive profile of nuclear dynamics during human …

Estrogen-related receptors (ERR) α and γ were shown recently to serve as regulators of
cardiac maturation, yet the underlying mechanisms have not been delineated. Herein, we …

Background: Surviving cells in the postinfarction border zone are subjected to intense
fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been …

Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Analyzing
hundreds of hiPSCs derived from different individuals, we show the proportions of these …