Bone has a remarkable endogenous regenerative capacity that enables scarless healing
and restoration of its prior mechanical function, even under challenging conditions such as …

The tumor microenvironment (TME) is a complex macromolecular network filled with a series
of stromal cells. It plays an important role in tumorigenesis, development, immune escape …

Extracellular biophysical properties have particular implications for a wide spectrum of
cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene …

The matrix stiffness of the extracellular matrix (ECM), which is the slow elastic force on cells,
has gradually become investigated. And a higher stiffness could induce changes in cell …

The association between kidney stone disease and renal fibrosis has been widely explored
in recent years but its underlying mechanisms remain far from complete understanding …

Tendon injuries are a major clinical problem, with poor patient outcomes caused by
abundant scar tissue deposition during healing. Myofibroblasts play a critical role in the …

Management of skin injuries imposes a substantial financial burden on patients and
hospitals, leading to diminished quality of life. Periostin (rhOSF), an extracellular matrix …

Matricellular proteins (MCPs) are defined as extracellular matrix (ECM) associated proteins
that are important regulators and integrators of microenvironmental signals, contributing to …

Chronic, non-healing, dermal wounds form a worldwide medical problem with limited and
inadequate treatment options and high societal burden and costs. With the advent of …

The formation of bone in a bone defect is accomplished by osteoblasts, while the over
activation of fibroblasts promotes fibrosis. However, it is not clear how the extracellular …