Each year, endometrial cancer develops in about 142 000 women worldwide, and an
estimated 42 000 women die from this cancer. The typical age-incidence curve for …

The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy
is associated with increases in genomic instability. Mitotic chromosomal instability—the …

Two types of endometrial carcinoma are distinguished with respect to biology and clinical
course. Type-I carcinoma is related to hyperestrogenism by association with endometrial …

This review paper discusses the main molecular alterations of endometrial carcinoma, the
most common cancer of the female genital tract. Two clinicopathological variants are …

The human aurora family of serine-threonine kinases comprises three members, which act
in concert with many other proteins to control chromosome assembly and segregation …

Purpose: The presence of similar histologic subtypes of epithelial ovarian and endometrial
cancers has long been noted, although the relevance of this finding to pathogenesis and …

Abstract The transcription factors Snail, Slug, and bHLH E47 have been recently described
as direct repressors of E-cadherin and inducers of epithelial-mesenchymal transition (EMT) …

Microarray technology has broadened the insight into many research fields allowing
scientists to analyse the expression of many genes in quick and efficient experiments aimed …

In the western world, endometrial carcinoma (EC) is the most common cancer of the female
genital tract. The annual incidence has been estimated at 10–20 per 100 000 women. Two …

In the Western world, endometrial carcinoma is the most common malignant tumour of the
female genital tract and the fourth most common cancer in women after carcinomas of …