The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates
during development in Drosophila and Caenorhabditis elegans. Studies on the expression …

The major arteries and veins of the vertebrate circulatory system are formed early in
embryonic development, before the onset of circulation, following de novo aggregation of …

Alagille syndrome is an autosomal dominant disorder characterized by abnormal
development of liver, heart, skeleton, eye, face and, less frequently, kidney. Analyses of …

Epithelial-to-mesenchymal transition (EMT) is fundamental to both embryogenesis and
tumor metastasis. The Notch intercellular signaling pathway regulates cell fate determination …

The Notch gene family encodes large transmembrane receptors that are components of an
evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 …

Recent evidence indicates that acquisition of artery or vein identity during vascular
development is governed, in part, by genetic mechanisms. The artery-specific expression of …

The Notch gene of Drosophila encodes a large transmembrane protein involved in cell fate
determination during embryonic and larval development. This gene is evolutionarily …

Notch is an evolutionarily conserved local cell signaling mechanism that participates in a
variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis …

Ventricular chamber morphogenesis, first manifested by trabeculae formation, is crucial for
cardiac function and embryonic viability and depends on cellular interactions between the …

Two distinct mechanisms, vasculogenesis and angiogenesis implement the formation of the
vascular network in the embryo. Vasculogenesis gives rise to the heart and the first primitive …