The major arteries and veins of the vertebrate circulatory system are formed early in embryonic development, before the onset of circulation, following de novo aggregation of …
L Li, ID Krantz, YU Deng, A Genin, AB Banta… - Nature …, 1997 - nature.com
Alagille syndrome is an autosomal dominant disorder characterized by abnormal development of liver, heart, skeleton, eye, face and, less frequently, kidney. Analyses of …
Epithelial-to-mesenchymal transition (EMT) is fundamental to both embryogenesis and tumor metastasis. The Notch intercellular signaling pathway regulates cell fate determination …
LT Krebs, Y Xue, CR Norton, JR Shutter… - Genes & …, 2000 - genesdev.cshlp.org
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 …
ND Lawson, N Scheer, VN Pham, CH Kim, AB Chitnis… - 2001 - journals.biologists.com
Recent evidence indicates that acquisition of artery or vein identity during vascular development is governed, in part, by genetic mechanisms. The artery-specific expression of …
PJ Swiatek, CE Lindsell, FF Del Amo… - Genes & …, 1994 - genesdev.cshlp.org
The Notch gene of Drosophila encodes a large transmembrane protein involved in cell fate determination during embryonic and larval development. This gene is evolutionarily …
Notch is an evolutionarily conserved local cell signaling mechanism that participates in a variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis …
Ventricular chamber morphogenesis, first manifested by trabeculae formation, is crucial for cardiac function and embryonic viability and depends on cellular interactions between the …
S Patan - Angiogenesis in brain tumors, 2004 - Springer
Two distinct mechanisms, vasculogenesis and angiogenesis implement the formation of the vascular network in the embryo. Vasculogenesis gives rise to the heart and the first primitive …