Tetralactam-based anion transporters

AM Gilchrist, DA McNaughton, M Fares, X Wu… - Chem, 2025 - cell.com
Synthetic anion transporters provide a promising avenue to treat diseases such as cystic
fibrosis and cancer. Anion binding site preorganization is one aspect of transporter design …

Alternative Oxidase: From Molecule and Function to Future Inhibitors

J Li, S Yang, Y Wu, R Wang, Y Liu, J Liu, Z Ye… - ACS …, 2024 - ACS Publications
In the respiratory chain of the majority of aerobic organisms, the enzyme alternative oxidase
(AOX) functions as the terminal oxidase and has important roles in maintaining metabolic …

Identifying and explaining the regioselectivity of alkylation of 1, 2, 4-triazole-3-thiones using NMR, GIAO and DFT methods

M Fizer, M Slivka, N Korol, O Fizer - Journal of Molecular Structure, 2021 - Elsevier
The regioselectivity of the alkylation of four 1, 2, 4-triazole-3-thiones with eight different
organic halides was determined by the comparison of experimentally observed NMR …

Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?

M Szibor, C Schenkl, MRO Barsottini… - Biochemical …, 2022 - portlandpress.com
Some of the most threatening human diseases are due to a blockage of the mitochondrial
electron transport chain (ETC). In a variety of plants, fungi, and prokaryotes, there is a …

Discovery of N-(1, 3, 4-thiadiazol-2-yl) benzamide derivatives containing a 6, 7-methoxyquinoline structure as novel EGFR/HER-2 dual-target inhibitors against cancer …

X Li, D Wang, S Li, W Xue, X Qian, K Liu, Y Li, Q Lin… - Bioorganic …, 2022 - Elsevier
Targeting EGFR and HER-2 is an essential direction for cancer treatment. Here, a series of
N-(1, 3, 4-thiadiazol-2-yl) benzamide derivatives containing a 6, 7-methoxyquinoline …

Switchable Site-Selective Benzanilide C(sp2)-H Bromination via Promoter Regulation

Y Sun, Q He, X Lv, N Zhang, W Yan, J Sun, L Zhuang - Molecules, 2024 - mdpi.com
Regioselective benzanilide bromination that generates either regioisomer from the same
starting material is desirable. Herein, we develop switchable site-selective C (sp2)-H …