Gravity as a Knob for Tuning Particle Size Distributions of Small Molecules

K Pal, A Radocea - Crystal Growth & Design, 2024 - ACS Publications
Pharmaceutical research and development and manufacturing can widely benefit from a
microgravity environment. Although the use of microgravity to improve control over the size …

[HTML][HTML] Solubility, aggregation and stability of Amphotericin B drug in pure organic solvents: Thermodynamic analysis and solid form characterization

R Soto, P Patel, AB Albadarin, MO Diniz… - Journal of Molecular …, 2022 - Elsevier
The solubility of amphotericin B (AmB) has been studied between temperatures of 298–343
K in a range of pure organic solvents including methanol, ethanol, isopropanol, butanol …

Greening the Waves: Experimental and Chemometric Approaches in Spectroscopic Methods for Organic Pollutant Determination in Natural Waters

G Borah, A Borah, C Hasnu - Environmental Science: Advances, 2024 - pubs.rsc.org
This review paper provides a comprehensive exploration of innovative strategies to enhance
the sustainability and efficacy of water quality monitoring. The global prevalence of organic …

Machine learning analysis of rivaroxaban solubility in mixed solvents for application in pharmaceutical crystallization

M Alqarni, A Alqarni - Scientific Reports, 2025 - nature.com
This study investigates the use of machine learning models to predict solubility of
rivaroxaban in binary solvents based on temperature (T), mass fraction (w), and solvent type …

[HTML][HTML] PLLA Scaffolds Functionalized with Ketoprofen via Rotary Jet Spinning for Biomedical Applications

FL Dantas, JHR Llanos, ICP Rodrigues… - Journal of Materials …, 2024 - Elsevier
Biopolymer-based biomaterials, such as poly (L-lactic acid)(PLLA), have long been
recognized as scaffolds for drug delivery applications due to their advantages, including …

Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX …

P Cysewski, T Jeliński, M Przybyłek, A Mai, J Kułak - Molecules, 2024 - mdpi.com
Deep eutectic solvents (DESs) are commonly used in pharmaceutical applications as
excellent solubilizers of active substances. This study investigated the tuning of ibuprofen …

[HTML][HTML] Thermodynamic solubility measurement without chemical analysis

E Hokkala, CJ Strachan, M Agopov, E Järvinen… - International Journal of …, 2024 - Elsevier
In this work, the optical imaging based single particle analysis (SPA) and the gold standard
shake-flask (SF) solubility methods are compared. We show that to analyze pharmaceutical …

Rational scale-up of catalytic hydrogenation involving slowly dissolving reactants

F Nanto, D Ciato, P Canu - Chemical Engineering Science, 2024 - Elsevier
Based on an experimental campaign, a model is developed for scaling up a fed-batch
catalytic hydrogenation, characterized by a slow dissolution of the reagent. The model …

Temperature Dependence of Solubility Predicted from Thermodynamic Data Measured at a Single Temperature: Application to α, β, and γ-Glycine

A Manson, J Sefcik, L Lue - Crystal Growth & Design, 2022 - ACS Publications
Understanding of solid–liquid equilibria for polymorphic systems is crucial for rational design
and efficient operation of crystallization processes. In this work, we present a framework to …

Enhancement of pioglitazone hydrochloride solubility through liquisolid compact formulation using novel carrier neusilin Us2

BR Rane, DS Gaikwad, AS Jain… - …, 2022 - pharmacophorejournal.com
The efficacy of the drug depends on the availability of bioavailability depending on the
melting of the drug cells. One of the most crucial factors in achieving the desired drug …