Computational tools and resources for CRISPR/Cas genome editing
The past decade has witnessed a rapid evolution in identifying more versatile clustered
regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) …
regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) …
Applying CRISPR-Cas9 screens to dissect hematological malignancies
DN Iyer, AD Schimmer, H Chang - Blood Advances, 2023 - ashpublications.org
Bit by bit, over the last few decades, functional genomic tools have been piecing together the
molecular puzzle driving tumorigenesis in human patients. Nevertheless, our understanding …
molecular puzzle driving tumorigenesis in human patients. Nevertheless, our understanding …
Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth
Colorectal cancer is the third leading cause of cancer-related deaths in the United States
and the third most common cancer in men and women. Around 20% colon cancer cases are …
and the third most common cancer in men and women. Around 20% colon cancer cases are …
In vivo Screening Reveals Epigenetic Regulation of Mammary Epithelial Lineage Integrity and Tumorigenesis
E Langille - 2023 - search.proquest.com
Systematic investigation of the scores of genes mutated in cancer to discern disease drivers
from inconsequential bystanders is a prerequisite for precision medicine but remains …
from inconsequential bystanders is a prerequisite for precision medicine but remains …
Functional genomic studies of cancer immune evasion using in vitro and in vivo CRISPR/Cas9 genetic screens
DA Garyfallos - 2021 - repository.cam.ac.uk
Recent advances in cancer immunology have shed light on the mechanisms of cancer
immune evasion. An accumulation of data in recent years has identified several immune …
immune evasion. An accumulation of data in recent years has identified several immune …