Uric acid and cardiovascular disease

G Ndrepepa - Clinica chimica acta, 2018 - Elsevier
Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?

RJ Johnson, DH Kang, D Feig, S Kivlighn, J Kanellis… - …, 2003 - Am Heart Assoc
Hyperuricemia is associated with hypertension, vascular disease, renal disease, and
cardiovascular events. In this report, we review the epidemiologic evidence and potential …

The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis

P Anagnostis, VG Athyros, K Tziomalos… - The Journal of …, 2009 - academic.oup.com
Context: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities that
increase the risk for type 2 diabetes mellitus and vascular disease. The common …

Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?

Z Soltani, K Rasheed, DR Kapusta, E Reisin - Current hypertension …, 2013 - Springer
Elevated serum uric acid concentration is a common laboratory finding in subjects with
metabolic syndrome/obesity, hypertension, kidney disease and cardiovascular events …

Relationship between hyperuricemia and lipid profiles in US adults

TC Peng, CC Wang, TW Kao, JYH Chan… - BioMed research …, 2015 - Wiley Online Library
Background. Although the link between hyperuricemia and metabolic syndrome had been
recognized, the association of the dyslipidemia among individuals with hyperuricemia …

Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease

VWS Wong, GLH Wong, GWK Yip, AOS Lo… - Gut, 2011 - gut.bmj.com
Objective Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome and is associated with cardiovascular risk. The aim of this study was to determine …

Serum uric acid and cardiovascular disease: recent developments, and where do they leave us?

JF Baker, E Krishnan, L Chen… - The American journal of …, 2005 - Elsevier
The relationship between serum uric acid (SUA) and cardiovascular disease has been
controversial. Here we review recent literature assessing whether hyperuricemia is an …

Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies

T Zuo, X Liu, L Jiang, S Mao, X Yin, L Guo - BMC cardiovascular disorders, 2016 - Springer
Background Hyperuricemia may be associated with an increased risk of coronary heart
disease (CHD) mortality; however, the results from prospective studies are conflicting. The …

Association of uric acid with change in kidney function in healthy normotensive individuals

G Bellomo, S Venanzi, C Verdura, P Saronio… - American Journal of …, 2010 - Elsevier
BACKGROUND: Despite recent evidence, the role of uric acid as a causal factor in the
pathogenesis and progression of kidney disease remains controversial, partly because of …

Uric acid: role in cardiovascular disease and effects of losartan

M Alderman, KJV Aiyer - Current medical research and opinion, 2004 - Taylor & Francis
SUMMARY A substantial body of epidemiological and experimental evidence suggests that
serum uric acid is an important, independent risk factor for cardiovascular and renal disease …