All hematopoietic and immune cells are continuously generated by hematopoietic stem cells
(HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of …

Osteoporosis (OP) is a skeletal disorder characterized by decreased bone density,
alterations in bone microstructure, and increased damage to the bones. As the population …

Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …

Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the
potential to contribute to both local and systemic metabolic processes. In this review we …

Kawai M, de Paula FJA, Rosen CJ (Osaka Medical Center and Research Institute for
Maternal and Child Health, Izumi, Osaka, Japan; University of São Paulo, Ribeirão Preto …

Aging is associated with decreased immune function that leads to increased morbidity and
mortality in the elderly. Immune senescence is accompanied by age-related changes in two …

Peroxisome proliferator-activated receptor γ (PPARγ) is a critical factor for adipogenesis and
glucose metabolism, but accumulating evidence demonstrates the involvement of PPARγ in …

Reports of the bone‐protective effects of resveratrol, a naturally occurring phytoestrogen and
agonist for the longevity gene SIRT1, have highlighted this compound as a candidate for …

Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth
factor-β (TGF-β) superfamily. They play multiple functions during development and tissue …

Individuals with type 2 diabetes mellitus (T2DM) have an increased risk of bone fragility
fractures compared to nondiabetic subjects. This increased fracture risk may occur despite …