Natural peptides inducing cancer cell death: Mechanisms and properties of specific candidates for cancer therapeutics

PA Trinidad-Calderón, CD Varela-Chinchilla… - Molecules, 2021 - mdpi.com
Nowadays, cancer has become the second highest leading cause of death, and it is
expected to continue to affect the population in forthcoming years. Additionally, treatment …

Lipids in pathophysiology and development of the membrane lipid therapy: new bioactive lipids

M Torres, S Parets, J Fernández-Díaz, R Beteta-Göbel… - Membranes, 2021 - mdpi.com
Membranes are mainly composed of a lipid bilayer and proteins, constituting a checkpoint
for the entry and passage of signals and other molecules. Their composition can be …

A short prokaryotic Argonaute activates membrane effector to confer antiviral defense

Z Zeng, Y Chen, R Pinilla-Redondo, SA Shah, F Zhao… - Cell host & …, 2022 - cell.com
Argonaute (Ago) proteins are widespread nucleic-acid-guided enzymes that recognize
targets through complementary base pairing. Although, in eukaryotes, Agos are involved in …

Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis

X Chen, X Song, J Li, R Zhang, C Yu, Z Zhou, J Liu… - Autophagy, 2023 - Taylor & Francis
Selective macroautophagy/autophagy maintains cellular homeostasis through the lysosomal
degradation of specific cellular proteins or organelles. The pro-survival effect of selective …

Cell-penetrating peptides derived from animal venoms and toxins

G Rádis-Baptista - Toxins, 2021 - mdpi.com
Cell-penetrating peptides (CPPs) comprise a class of short polypeptides that possess the
ability to selectively interact with the cytoplasmic membrane of certain cell types, translocate …

The biological role of charge distribution in linear antimicrobial peptides

HM Duque, G Rodrigues, LS Santos… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Antimicrobial peptides (AMP) have received particular attention due to their
capacity to kill bacteria. Although much is known about them, peptides are currently being …

Beyond pore formation: Reorganization of the plasma membrane induced by pore-forming proteins

M Kulma, G Anderluh - Cellular and Molecular Life Sciences, 2021 - Springer
Pore-forming proteins (PFPs) are a heterogeneous group of proteins that are expressed and
secreted by a wide range of organisms. PFPs are produced as soluble monomers that bind …

Membrane dynamics and remodelling in response to the action of the membrane-damaging pore-forming toxins

K Lata, M Singh, S Chatterjee… - The Journal of Membrane …, 2022 - Springer
Pore-forming protein toxins (PFTs) represent a diverse class of membrane-damaging
proteins that are produced by a wide variety of organisms. PFT-mediated membrane …

Peptide-based nanoparticles for systemic extrahepatic delivery of therapeutic nucleotides

SA Wickline, KK Hou, H Pan - International journal of molecular sciences, 2023 - mdpi.com
Peptide-based nanoparticles (PBN) for nucleotide complexation and targeting of
extrahepatic diseases are gaining recognition as potent pharmaceutical vehicles for fine …

[PDF][PDF] Small-angle scattering from flat bilayers containing correlated scattering length density inhomogeneities

F Spinozzi, LRS Barbosa, G Corucci… - Journal of Applied …, 2023 - journals.iucr.org
Model lipid bilayers have been widely employed as a minimal system to investigate the
structural properties of biological membranes by small-angle X-ray (SAXS) and neutron …