Paediatric and adult glioblastoma: multiform (epi) genomic culprits emerge
We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
[HTML][HTML] bHLH transcription factors in neural development, disease, and reprogramming
DJ Dennis, S Han, C Schuurmans - Brain research, 2019 - Elsevier
The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …
requires that appropriate numbers of the correct types of neuronal and glial cells are …
Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
QR Lu, T Sun, Z Zhu, N Ma, M Garcia, CD Stiles… - Cell, 2002 - cell.com
The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are
coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on …
coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on …
Primary brain tumours in adults
A Behin, K Hoang-Xuan, AF Carpentier, JY Delattre - The Lancet, 2003 - thelancet.com
The most frequent primary brain tumours in adults are gliomas and primary CNS
lymphomas. In gliomas, molecular genetic analysis plays an increasing part in classification …
lymphomas. In gliomas, molecular genetic analysis plays an increasing part in classification …
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte …
RM Bachoo, EA Maher, KL Ligon, NE Sharpless… - Cancer cell, 2002 - cell.com
Ink4a/Arf inactivation and epidermal growth factor receptor (EGFR) activation are signature
lesions in high-grade gliomas. How these mutations mediate the biological features of these …
lesions in high-grade gliomas. How these mutations mediate the biological features of these …
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma
Recent studies have identified stem cells in brain cancer. However, their relationship to
normal CNS progenitors, including dependence on common lineage-restricted pathways, is …
normal CNS progenitors, including dependence on common lineage-restricted pathways, is …
Personalized immunotherapy against several neuronal and brain tumors
S Kuttruff-coqui, T Weinschenk, J Fritsche… - US Patent …, 2021 - Google Patents
2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas
Astrocytomas, oligodendrogliomas, and oligoastrocytomas, collectively referred to as diffuse
gliomas, are the most common primary brain tumors. These tumors are classified by …
gliomas, are the most common primary brain tumors. These tumors are classified by …
Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter
A defining feature of glial cells has been their inability to generate action potentials. We
show here that there are two distinct types of morphologically identical oligodendrocyte …
show here that there are two distinct types of morphologically identical oligodendrocyte …
The developmental origin of brain tumours: a cellular and molecular framework
The development of the nervous system relies on the coordinated regulation of stem cell self-
renewal and differentiation. The discovery that brain tumours contain a subpopulation of …
renewal and differentiation. The discovery that brain tumours contain a subpopulation of …