Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

A guide to uncertainty quantification and sensitivity analysis for cardiovascular applications

VG Eck, WP Donders, J Sturdy… - … journal for numerical …, 2016 - Wiley Online Library
As we shift from population‐based medicine towards a more precise patient‐specific regime
guided by predictions of verified and well‐established cardiovascular models, an urgent …

Endothelial dysfunction in the pathogenesis of abdominal aortic aneurysm

E DeRoo, A Stranz, H Yang, M Hsieh, C Se, T Zhou - Biomolecules, 2022 - mdpi.com
Abdominal aortic aneurysm (AAA), defined as a focal dilation of the abdominal aorta beyond
50% of its normal diameter, is a common and potentially life-threatening vascular disease …

Intraluminal thrombus predicts rapid growth of abdominal aortic aneurysms

C Zhu, JR Leach, Y Wang, W Gasper, D Saloner… - Radiology, 2020 - pubs.rsna.org
Background Intraluminal thrombus (ILT) within abdominal aortic aneurysms (AAAs) may be
a potential marker for subsequent aneurysm growth. Purpose To investigate the role of ILT in …

Geometric and biomechanical modeling aided by machine learning improves the prediction of growth and rupture of small abdominal aortic aneurysms

M Lindquist Liljeqvist, M Bogdanovic, A Siika… - Scientific reports, 2021 - nature.com
It remains difficult to predict when which patients with abdominal aortic aneurysm (AAA) will
require surgery. The aim was to study the accuracy of geometric and biomechanical analysis …

Ruptured abdominal aortic aneurysm—epidemiology, predisposing factors, and biology

T Schmitz-Rixen, M Keese, M Hakimi, A Peters… - … archives of surgery, 2016 - Springer
Purpose Abdominal aortic aneurysm is a common degenerative vascular disorder
associated with sudden death due to aortic rupture. This review describes epidemiology …

The abdominal aortic aneurysm and intraluminal thrombus: current concepts of development and treatment

A Piechota-Polanczyk, A Jozkowicz… - Frontiers in …, 2015 - frontiersin.org
The pathogenesis of the abdominal aortic aneurysm (AAA) shows several hallmarks of
atherosclerotic and atherothrombotic disease, but comprises an additional, predominant …

Antithrombotic therapy in abdominal aortic aneurysm: beneficial or detrimental?

SJ Cameron, HM Russell… - Blood, The Journal of the …, 2018 - ashpublications.org
Abdominal aortic aneurysm (AAA) is a degenerative vascular pathology resulting in
significant morbidity and mortality in older adults due to rupture and sudden death. Despite …

Biochemomechanics of intraluminal thrombus in abdominal aortic aneurysms

JS Wilson, L Virag, P Di Achille… - Journal of …, 2013 - asmedigitalcollection.asme.org
Most computational models of abdominal aortic aneurysms address either the
hemodynamics within the lesion or the mechanics of the wall. More recently, however, some …