Progressive multifocal leukoencephalopathy (PML) is a rare but often fatal brain disease
caused by reactivation of the polyomavirus JC. Knowledge of the characteristics of PML has …

Natalizumab, a highly specific α4-integrin antagonist, is approved for treatment of patients
with active relapsing-remitting multiple sclerosis (RRMS). It is generally recommended for …

This report updates and combines earlier versions of guidelines for the prevention and
treatment of opportunistic infections (OIs) in HIV-infected adults (ie, persons aged> 18 years) …

Survival in people infected with HIV has improved because of an increasingly powerful array
of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including …

This report updates and combines into one document earlier versions of guidelines for
preventing and treating opportunistic infections (OIs) among HIV-exposed and HIV-infected …

Background. Human immunodeficiency virus (HIV) infection predisposes to progressive
multifocal leukoencephalopathy (PML). Here, we describe the incidence, presentation, and …

Polyomaviruses are ubiquitous, species-specific viruses belonging to the family
Papovaviridae. The two most commonly known human polyomaviruses, BK virus and JC …

A drastic decrease in incidence has been observed for most human immunodeficiency virus
(HIV)–related opportunistic manifestations after use of highly active antiretroviral therapy …

JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964,
PyV particles were revealed by electron microscopy in progressive multifocal …

Nothing is more disappointing for patients than when a promising new treatment hits a
roadblock because of unexpected side effects. This is what happened when natalizumab …