Covering: up to 2012 The glycosylation of microbial natural products often dramatically
influences the biological and/or pharmacological activities of the parental metabolite. Over …

The flavoenzyme UDP-galactopyranose mutase (UGM) is a key enzyme in galactofuranose
biosynthesis. The enzyme catalyzes the 6-to-5 ring contraction of UDP-galactopyranose to …

UDP-Galactopyranose mutase (UGM) is a flavin-containing enzyme that catalyzes the
reversible conversion of UDP-galactopyranose (UDP-Gal p) to UDP-galactofuranose (UDP …

Glycans and glycosylated biomolecules are directly involved in almost every biological
process as well as the etiology of most major diseases. Hence, glycoscience knowledge is …

Sugar-nucleotides are imperative to carbohydrate metabolism and glycoconjugate
biosynthesis. Enzymatic methods to access these key materials offer a powerful alternative …

This study reports a novel class of inhibitors of uridine 5′‐diphosphate (UDP)
galactopyranose mutase (UGM) derived from a screening of natural products. This enzyme …

Three groups of furanoses with restricted freedom of rotation on the C3–C4, C2–C3, and C1–
C2 bonds, respectively, are presented. Conformational analysis of these furanoses is …

Galactofuranose (Gal f) is present in glycans critical for the virulence and viability of several
pathogenic microbes, including Mycobacterium tuberculosis, yet the monosaccharide is …

For three decades the C4a-position of reduced flavins was the known site for covalency
within flavoenzymes. The reactivity of this position of the reduced isoalloxazine ring with the …

Leishmania, a protozoan parasite that causes leishmaniasis, affects 1‐2 million people
every year worldwide. Leishmaniasis is a vector born disease and characterized by a …