Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in
the bone marrow (BM). Despite the significant advances in treatment, MM is still a fatal …

The Wnt signaling pathway plays an important role not only in embryonic development but
also in the maintenance and differentiation of the stem cells in adulthood. In particular, Wnt …

The processes of bone growth, modeling, and remodeling determine the structure, mass,
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …

Substantial advances have been made in understanding the biology of multiple myeloma
(MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche …

Osteoporosis is a skeletal disorder characterized by bone loss, which results in architectural
deterioration of the skeleton, compromised bone strength and an increased risk of fragility …

Wnt signaling affects both bone modeling, which occurs during development, and bone
remodeling, which is a lifelong process involving tissue renewal. Wnt signals are especially …

Wnt/β-catenin signaling is central to bone development and homeostasis in adulthood and
its deregulation is associated with bone pathologies. Dickkopf-1 (DKK1), a soluble inhibitor …

Multiple myeloma (MM) is a neoplasm of post–germinal center, terminally differentiated B
cells. It is characterized by a multifocal proliferation of clonal, long-lived plasma cells within …

Understanding the pathogenesis of cancer-related bone disease is crucial to the discovery
of new therapies. Here we identify activin A, a TGF-β family member, as a therapeutically …

Background: There is a need to develop new bone anabolic agents because current bone
regeneration regimens have limitations. The Wingless-type MMTV integration site (Wnt) …