Yeasts represent a group of the microorganisms most frequently seen in biotechnology.
Recently, the class 2 type II CRISPR system (CRISPR/Cas9) has become the principal …

Aspergillus flavus is a ubiquitous saprotrophic soil‐borne pathogenic fungus that causes
crops contamination with the carcinogen aflatoxins. Although sirtuin E (SirE) is known to be …

Telomeres, repetitive sequences located at the ends of most eukaryotic chromosomes,
provide a mechanism to replenish terminal sequences lost during DNA replication, limit …

Exposure of eukaryotic cells to ionizing radiation or clastogenic chemicals leads to formation
of DNA double-strand breaks (DSBs). These lesions are also generated internally by …

The breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, are key players in
the homologous recombination (HR) repair pathway and act as tumor suppressors by …

Aging is defined as a progressive decline in physiological integrity, leading to impaired
biological function, including fertility, and rising vulnerability to death. Disorders of DNA …

Several sources of DNA damage compromise the integrity and stability of the genome of
every organism. Specifically, DNA double-strand breaks (DSBs) can have lethal …

Telomere healing occurs when telomerase, normally restricted to chromosome ends, acts
upon a double-strand break to create a new, functional telomere. De novo telomere addition …

Evolution is driven by the accumulation of competing mutations that influence survival. A
broad form of genetic variation is the amplification or deletion of DNA (≥ 50 bp) referred to …

Telomeres, maintained by the enzyme telomerase, are GT-rich, highly repetitive sequences
at the ends of most eukaryotic chromosomes. Telomeres protect chromosome ends from …