Prognostic gene expression profiling in cutaneous melanoma: identifying the knowledge gaps and assessing the clinical benefit

D Grossman, N Okwundu, EK Bartlett… - JAMA …, 2020 - jamanetwork.com
Importance Use of prognostic gene expression profile (GEP) testing in cutaneous melanoma
(CM) is rising despite a lack of endorsement as standard of care. Objective To develop …

Prognostic biomarkers of cutaneous melanoma

L Ding, A Gosh, DJ Lee, G Emri… - Photodermatology …, 2022 - Wiley Online Library
Background/purpose Melanomas account for only approximately 4% of diagnosed skin
cancers in the United States but are responsible for the majority of deaths caused by skin …

[HTML][HTML] Molecular risk prediction in cutaneous melanoma: A meta-analysis of the 31-gene expression profile prognostic test in 1,479 patients

BN Greenhaw, KR Covington, SJ Kurley… - Journal of the American …, 2020 - Elsevier
Background Multiple studies have reported on the accuracy of the prognostic 31-gene
expression profile test for cutaneous melanoma. Consistency of the test results across …

Performance of gene expression profile tests for prognosis in patients with localized cutaneous melanoma: a systematic review and meta-analysis

MA Marchetti, DG Coit, SW Dusza, A Yu… - JAMA …, 2020 - jamanetwork.com
Importance The performance of prognostic gene expression profile (GEP) tests for
cutaneous melanoma is poorly characterized. Objective To systematically assess the …

Long-term outcomes in a multicenter, prospective cohort evaluating the prognostic 31-gene expression profile for cutaneous melanoma

EC Hsueh, JR DeBloom, JH Lee, JJ Sussman… - JCO Precision …, 2021 - ascopubs.org
PURPOSE Current guidelines for postoperative management of patients with stage I-IIA
cutaneous melanoma (CM) do not recommend routine cross-sectional imaging, yet many of …

[HTML][HTML] Optimizing treatment approaches for patients with cutaneous melanoma by integrating clinical and pathologic features with the 31-gene expression profile test

A Jarell, BR Gastman, LD Dillon, EC Hsueh… - Journal of the American …, 2022 - Elsevier
Background Many patients with low-stage cutaneous melanoma will experience tumor
recurrence, metastasis, or death, and many higher staged patients will not. Objective To …

Molecular biomarkers for melanoma screening, diagnosis and prognosis: current state and future prospects

DC Deacon, EA Smith, RL Judson-Torres - Frontiers in Medicine, 2021 - frontiersin.org
Despite significant progress in the development of treatment options, melanoma remains a
leading cause of death due to skin cancer. Advances in our understanding of the genetic …

Expert consensus on the use of prognostic gene expression profiling tests for the management of cutaneous melanoma: consensus from the skin cancer prevention …

AS Farberg, JW Marson, A Glazer, GH Litchman… - Dermatology and …, 2022 - Springer
Background Prognostic assessment of cutaneous melanoma relies on historical,
clinicopathological, and phenotypic risk factors according to American Joint Committee on …

Role of biomarkers in the integrated management of melanoma

PP Naik - Disease Markers, 2021 - Wiley Online Library
Melanoma, which is an aggressive skin cancer, is currently the fifth and seventh most
common cancer in men and women, respectively. The American Cancer Society reported …

[HTML][HTML] Initial stage of cutaneous primary melanoma plays a key role in the pattern and timing of disease recurrence

SS Ertekin, S Podlipnik… - Acta Dermato …, 2021 - ncbi.nlm.nih.gov
Given recent developments in the treatment of metastatic melanoma, early detection of
disease recurrence is crucial. The aim of this single-centre retrospective cohort study was to …