Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

S Shi, Y Chen, Z Luo, G Nie, Y Dai - Cell Communication and Signaling, 2023 - Springer
Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

Extracellular vesicles as tools and targets in therapy for diseases

MA Kumar, SK Baba, HQ Sadida… - Signal transduction and …, 2024 - nature.com
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight …

K Jomova, SY Alomar, SH Alwasel, E Nepovimova… - Archives of …, 2024 - Springer
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …

Natural phytochemicals as SIRT activators—focus on potential biochemical mechanisms

M Wiciński, J Erdmann, A Nowacka, O Kuźmiński… - Nutrients, 2023 - mdpi.com
Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …

Dysfunctional and dysregulated nitric oxide synthases in cardiovascular disease: mechanisms and therapeutic potential

R Roy, J Wilcox, AJ Webb, K O'Gallagher - International journal of …, 2023 - mdpi.com
Nitric oxide (NO) plays an important and diverse signalling role in the cardiovascular system,
contributing to the regulation of vascular tone, endothelial function, myocardial function …

Canagliflozin mitigates carfilzomib-induced endothelial apoptosis via an AMPK-dependent pathway

MS Dabour, IY Abdelgawad, MKO Grant… - Biomedicine & …, 2023 - Elsevier
Carfilzomib (CFZ) is a proteasome inhibitor approved for relapsed/refractory multiple
myeloma (MM) but its clinical use is limited by cardiovascular toxicity. The mechanisms of …

[HTML][HTML] PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging

S Liu, J Wu, A Stolarz, H Zhang, M Boerma… - Theranostics, 2023 - ncbi.nlm.nih.gov
Aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that binds
to low-density lipoprotein receptors. Efferocytosis is the process by which phagocytes …

Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease

S Perumalsamy, HZ Huri, BM Abdullah, O Mazlan… - Metabolites, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a
background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic …

Acute and short-term beetroot juice nitrate-rich ingestion enhances cardiovascular responses following aerobic exercise in postmenopausal women with arterial …

CJR Benjamim, LSL da Silva, YBA Sousa… - Free Radical Biology …, 2024 - Elsevier
Background The increase in blood pressure (BP) levels in the postmenopausal period can
be partly explained by the decrease in nitric oxide synthases (NOS). Objective To investigate …

Effectiveness of anthocyanin-containing foods and nutraceuticals in mitigating oxidative stress, inflammation, and cardiovascular health-related biomarkers: a …

N Mohammadi, M Farrell, L O'Sullivan, A Langan… - Food & Function, 2024 - pubs.rsc.org
Cardiovascular diseases (CVDs) are a group of chronic health disorders prevalent
worldwide that claim millions of lives yearly. Inflammation and oxidative stress are intricately …