Predicting tumour radiosensitivity to deliver precision radiotherapy

JM Price, A Prabhakaran, CML West - Nature Reviews Clinical …, 2023 - nature.com
Owing to advances in radiotherapy, the physical properties of radiation can be optimized to
enable individualized treatment; however, optimization is rarely based on biological …

Biochemical recurrence in patients with prostate cancer after primary definitive therapy: treatment based on risk stratification

ND Shore, JW Moul, KJ Pienta, J Czernin… - Prostate Cancer and …, 2024 - nature.com
Background Nearly one-third of patients with prostate cancer (PCa) experience biochemical
recurrence (BCR) after primary definitive treatment. BCR increases the risk of distant …

[HTML][HTML] Management of patients with advanced prostate cancer. Part I: intermediate-/high-risk and locally advanced disease, biochemical relapse, and side effects of …

S Gillessen, A Bossi, ID Davis, J de Bono, K Fizazi… - European urology, 2023 - Elsevier
Background Innovations in imaging and molecular characterisation and the evolution of new
therapies have improved outcomes in advanced prostate cancer. Nonetheless, we continue …

Racial disparities in prostate cancer among black men: epidemiology and outcomes

IM Chowdhury-Paulino, C Ericsson… - Prostate cancer and …, 2022 - nature.com
Prostate cancer has the widest racial disparities of any cancer, and these disparities appear
at every stage of the cancer continuum. This review focuses on the disparities in prostate …

Using PSMA imaging for prognostication in localized and advanced prostate cancer

MJ Roberts, T Maurer, M Perera, M Eiber… - Nature Reviews …, 2023 - nature.com
The use of prostate-specific membrane antigen (PSMA)-directed applications in modern
prostate cancer management has evolved rapidly over the past few years, helping to …

Dose-escalated radiotherapy alone or in combination with short-term androgen deprivation for intermediate-risk prostate cancer: results of a phase III multi-institutional …

DJ Krauss, T Karrison, AA Martinez… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE It remains unknown whether or not short-term androgen deprivation (STAD)
improves survival among men with intermediate-risk prostate cancer (IRPC) treated with …

[HTML][HTML] Validation of the Decipher genomic classifier in patients receiving salvage radiotherapy without hormone therapy after radical prostatectomy–an ancillary …

A Dal Pra, P Ghadjar, S Hayoz, VYT Liu, DE Spratt… - Annals of oncology, 2022 - Elsevier
Background The Decipher genomic classifier (GC) has shown to independently
prognosticate outcomes in prostate cancer. The objective of this study was to validate the …

Best approaches and updates for prostate cancer biochemical recurrence

NI Simon, C Parker, TA Hope, CJ Paller - American Society of Clinical …, 2022 - ascopubs.org
Biochemical recurrence develops in almost one-third of men with prostate cancer after
treatment with local therapy. There are numerous options for management, including …

Genetic and genomic testing for prostate cancer: beyond DNA repair

C Herberts, AW Wyatt, PL Nguyen… - American Society of …, 2023 - ascopubs.org
Significant progress has been made in genetic and genomic testing for prostate cancer
across the disease spectrum. Molecular profiling is increasingly relevant for routine clinical …

Genomic testing in localized prostate cancer can identify subsets of African Americans with aggressive disease

S Awasthi, GD Grass, J Torres-Roca… - JNCI: Journal of the …, 2022 - academic.oup.com
Background Personalized genomic classifiers have transformed the management of
prostate cancer (PCa) by identifying the most aggressive subsets of PCa. Nevertheless, the …