MR is a powerful technique for studying the biomechanical and functional properties of
skeletal muscle in vivo in health and disease. This review focuses on 31P, 1H and 13C MR …

In the last decade, in vivo MR methods have become established tools in the drug discovery
and development process. In this review, several successful and potential applications of …

The delay in skeletal muscle mitochondrial ATP production at the onset of exercise is
thought to be a function of a limited oxygen supply. The delay, termed the oxygen deficit, can …

AMP deaminase activity (AMP IMP+ NH 3) is the entry reaction to the purine nucleotide
cycle. In skeletal muscle, excessive energy demands during contractions leads to a net …

▪ Abstract Transgenic and eugenic animals as small as 30 g can be studied noninvasively by
radionuclides with resolutions of 1–2 mm, by MRI with resolution of 100 μm and by light …

We have demonstrated previously that dichloroacetate can attenuate skeletal muscle fatigue
by up to 35% in a canine model of peripheral ischemia (Timmons, JA, SM Poucher, D …

Energy balance refers to the dynamic homeostasis of ATP and related forms of chemical
potential within cells. This regulation is accomplished mainly by oxidative metabolism in …

Viable genetically engineered animals generally exhibit adaptations to the altered genotype,
which may mask the role of the protein of interest. We now describe a novel method by …

Creatine kinase (CK) is a highly conserved enzyme abundant in skeletal muscle that has a
key role in high energy phosphate metabolism. The localization of the muscle isoenzyme of …

Studies of transgenic mice provide powerful means to investigate the in vivo biological
significance of gene products. Mice with an under‐or overexpression of enzymes involved in …