Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various
macromolecules and micronutrients, which they can import through transmembrane …

SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family
and localized in the plasma membrane of several body districts. ASCT2 is an acronym …

Glutamine together with glucose is essential for body's homeostasis. It is the most abundant
amino acid and is involved in many biosynthetic, regulatory and energy production …

Using molecular, biochemical, and untargeted stable isotope tracing approaches, we
identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy …

The serum-and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and
under genomic control by cell stress (including cell shrinkage) and hormones (including …

Amplification and/or activation of the c‐Myc proto‐oncogene is one of the leading genetic
events along hepatocarcinogenesis. The oncogenic potential of c‐Myc has been proven …

Glutamine metabolism, described as major energy and building blocks supply to cell growth,
has gained great attention. Alanine-Serine-Cysteine Transporter (ASCT2), which belongs to …

The autophagy pathway is the process whereby cells keep cellular homeostasis and
respond to stress via recycling their damaged cellular proteins, organelles, and other …

▪ Abstract The serum/glucocorticoid-induced kinase Sgk1 plays an important role in the
regulation of epithelial ion transport. This kinase is very rapidly regulated at the …

Abstract The phosphatidylinositol 3′ kinase (PI3K)‐signaling pathway plays a critical role in
a variety of cellular responses such as modulation of cell survival, glucose homeostasis, cell …