Phosphorylation of proteins is reversibly controlled by the kinases and phosphatases in
many posttranslational regulation patterns. Protein phosphatase 5 (PPP5C) is a …

Transcriptional activity of p53, a central regulatory switch in a network controlling cell
proliferation and apoptosis, is modulated by protein stability and post-translational …

Although the aberrant actions of protein kinases have long been known to contribute to
tumor promotion and carcinogenesis, roles for protein phosphatases in the development of …

Following a proliferative phase of variable duration, most normal somatic cells enter a
growth arrest state known as replicative senescence. In addition to telomere shortening, a …

Diverse functions, including DNA replication, recombination and repair, occur during S
phase of the eukaryotic cell cycle. It has been proposed that p53 and BLM help regulate …

The importance of methylation in the tumorigenic responses of nonhistone proteins, such as
TP53, PTEN, RB1, AKT, and STAT3, has been emphasized in numerous studies. In parallel …

Abstract CP-31398, a styrylquinazoline, emerged from a high throughput screen for
therapeutic agents that restore a wild-type-associated epitope (monoclonal antibody 1620) …

ABSTRACT Simian virus 40 (SV40) large T antigen (LT) is a multifunctional protein that is
important for viral replication and oncogenic transformation. Previously, infection of monkey …

Human keratinocytes respond to UV rays by developing a fast adaptive response that
contributes to maintaining their functions and survival. We investigated the role of the …

Background The eukaryotic translation initiation factor 5A1 (eIF5A1) is a highly conserved
protein involved in many cellular processes including cell division, translation, apoptosis …