Frailty is a state of high vulnerability to adverse health outcomes. This concept is used to
explain the heterogeneity in rates of aging in people of the same age. Frailty has important …

Although survival has been the focus of aging research for many years, the field is rapidly
evolving towards incorporating healthspan and health indices in studies that explore aging …

Dietary protein restriction is increasingly recognized as a unique approach to improve
metabolic health, and there is increasing interest in the mechanisms underlying this …

As an organism ages, its health-state is determined by a balance between the processes of
damage and repair. Measuring these processes requires longitudinal data. We extract …

Polypharmacy is very common in frail older people, although medications are rarely
evaluated in this population. We conducted a narrative review of the effects of the biology of …

Heterogeneity in biological aging manifests itself in health status and mortality. Frailty
indices (FIs) capture health status in humans and model organisms. To accelerate our …

Key points Heart size increases with age (called hypertrophy), and its ability to contract
declines. However, these reflect average changes that may not be present, or present to the …

Although frailty has been extensively investigated for the last 2 decades, preclinical models
of frailty have only been developed over the past decade. Frailty is a concept that helps to …

We investigated effects of age, sex and frailty on contractions, calcium transients and
myofilament proteins to determine if maladaptive changes associated with aging were sex …

Frailty is an age-related condition characterized by a multisystem functional decline,
increased vulnerability to stressors, and adverse health outcomes. Quantifying the degree of …